ABCA4 Antikörper (C-Term)

Produktnummer ABIN4889493

Dieses Anti-ABCA4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ABCA4 in WB, IHC und ELISA. Geeignet für Human, Maus, Ratte und Affe.

Kurzübersicht für ABCA4 Antikörper (C-Term) (ABIN4889493)

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-ABCA4 Antikörper

Bindungsspezifität: C-Term

Spezifität: Reacts with primate ABCA4 protein: human, mouse, rat, dog, monkeys

Kreuzreaktivität (Details): ..

Aufreinigung: Purified (protein A)

Immunogen: Synthetic peptide derived from C terminal domain of human ABCA4 protein.

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only :
- WB : 1 to 5 μg/mL - IHC : 1/100 to 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Must be reconstituted in distilled water.

Konzentration: 1 mg/mL

Buffer: Tris 0,1M, glycine 0,1M, sucrose 2 %

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 24 months

Details zu ABCA4

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Andere Bezeichnung: Retinal-Specific ATP-Binding Cassette Transporter

Hintergrund: Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) . In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.

UniProt: P78363