KEAP1 Antikörper (C-Term)

Produktnummer ABIN4889301

Dieses Anti-KEAP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KEAP1 in WB, ELISA, IF und ICC. Geeignet für Human, Schwein und Meerschweinchen.

Kurzübersicht für KEAP1 Antikörper (C-Term) (ABIN4889301)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reaktivität: Human, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KEAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-KEAP1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Reacts with KEAP1 from human, pig, guinea pig, sheep and other species (due to 100 % sequence homology)

Aufreinigung: Purified (protein A)

Immunogen: Synthetic peptide of derived from C terminal part of human KEAP1.

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB(1:500 - 1:200) ICC/ IF(1:200 - 1:1000)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Must be reconstituted in distilled water.

Konzentration: 1 mg/mL

Buffer: Tris 0,1M, glycine 0,1M

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 6 months

Details zu KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Andere Bezeichnung: KEAP1

Hintergrund: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Gen-ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location