EGLN3 Antikörper (Internal Region)

Produktnummer ABIN4889115

Dieses Anti-EGLN3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EGLN3 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für EGLN3 Antikörper (Internal Region) (ABIN4889115)

Target: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGLN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-EGLN3 Antikörper

Bindungsspezifität: Internal Region

Spezifität: Reacts with EGLN3 from human, mouse and rat

Aufreinigung: Purified (protein A)

Immunogen: Synthetic peptide of derived from internal part of human EGLN3.

Anwendungsinformationen

Applikationshinweise:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC1:100 - 1:1000 WB1:200 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Must be reconstituted in distilled water.

Konzentration: 1 mg/mL

Buffer: Tris 0,1M, glycine 0,1M, sucrose 2 %

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Haltbarkeit: 24 months

Details zu EGLN3

Target: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))

Andere Bezeichnung: EGLN3

Hintergrund: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site.

Gen-ID: 112399

UniProt: Q9H6Z9

Pathways: Positive Regulation of Endopeptidase Activity