8-OHDG Antikörper

Produktnummer ABIN488679

Zitiert in 3+ Publikationen. Der Maus Monoklonal anti-8-OHDG Antikörper (Klon 15A3) (ABIN488679) detektiert spezifisch 8-OHDG in ELISA, AC und IHC (fp).

Kurzübersicht für 8-OHDG Antikörper (ABIN488679)

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser 8-OHDG Antikörper ist unkonjugiert

Applikation: ELISA, Affinity Chromatography (AC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: 15A3

Produktdetails anti-8-OHDG Antikörper

Verwendungszweck: Anti-8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)

Spezifität: Recognizes markers of oxidative damage to DNA (8-hydroxy-2?-deoxyguanosine,8-hydroxyguanine and 8-hydroxyguanosine).

Kreuzreaktivität (Details): Recognizes markers of oxidative damage to DNA (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine)
Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Aufreinigung: Protein G purified

Immunogen: 8-hydroxy-guanosine-BSA and - casein conjugates

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: The optimal working dilution should be determined by the investigator

Kommentare:

protocol for immunostaining using this antibody can be found here

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Total IgG fraction. Protein G purified.

Handhabung: Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube

Lagerung: -20 °C

Informationen zur Lagerung: Store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

Referenzen für anti-8-OHDG Antikörper (ABIN488679)

Haigh, Drew: "Cavitation during the protein misfolding cyclic amplification (PMCA) method--The trigger for de novo prion generation?" in: Biochemical and biophysical research communications, Vol. 461, Issue 3, pp. 494-500, (2015) (PubMed).

Bobal, Otevrel, Poborilova, Vaverkova, Csollei, Babula: "Application of BY-2 cell model in evaluating an effect of newly prepared potential calcium channel blockers." in: Pakistan journal of pharmaceutical sciences, Vol. 28, Issue 4, pp. 1281-93, (2015) (PubMed).

Pilger, Rüdiger: "8-Hydroxy-2'-deoxyguanosine as a marker of oxidative DNA damage related to occupational and environmental exposures." in: International archives of occupational and environmental health, Vol. 80, Issue 1, pp. 1-15, (2006) (PubMed).

Details zu 8-OHDG

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Andere Bezeichnung: 8-Hydroxyguanosine

Substanzklasse: Chemical

Hintergrund:

Background: Oxidative derivate of guanosine is called 8-Hydroxyguanosine (8OHdG) and is used as a popular biomarker of oxidative stress.

Additional information: Protein G purified IgG2B in PBS, pH 7,4 with 0,09 % sodium azide and 50 % glycerol at concentration 0,65 mg/mL