Cofilin 2 Antikörper (C-Term)

Produktnummer ABIN4886538

Dieser Anti-Cofilin 2 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Cofilin 2 in WB, IF, ICC und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Cofilin 2 Antikörper (C-Term) (ABIN4886538)

Target: Cofilin 2 (CFL2)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cofilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-Cofilin 2 Antikörper

Bindungsspezifität: AA 121-153, C-Term

Verwendungszweck: Anti-Cofilin 2/CFL2 Antibody

Sequenz: KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKL

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Cofilin 2/CFL2 Antibody (ABIN4886538). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cofilin 2, identical to the related mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Cofilin 2

Target: Cofilin 2 (CFL2)

Andere Bezeichnung: CFL2

Hintergrund:

Synonyms: Cofilin-2,Cofilin, muscle isoform,CFL2,

Tissue Specificity: Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Background: Cofilin 2 (muscle), also known as CFL2, is a protein which in humans is encoded by the CFL2 gene. It is mapped to 14q12. This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. And this protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH -dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 26 kDa

Gen-ID: 1073

UniProt: Q9Y281

Pathways: Caspase Kaskade in der Apoptose