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CA2 Antikörper (AA 2-260)

Dieses Anti-CA2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CA2 in WB, IHC, ICC, IF und FACS. Geeignet für Human, Ratte und Maus.
Produktnummer ABIN4886493

Kurzübersicht für CA2 Antikörper (AA 2-260) (ABIN4886493)

Target

Alle CA2 Antikörper anzeigen
CA2 (Carbonic Anhydrase II (CA2))

Reaktivität

  • 104
  • 51
  • 50
  • 15
  • 12
  • 12
  • 12
  • 10
  • 10
  • 5
  • 4
  • 4
  • 3
  • 2
  • 1
Human, Ratte, Maus

Wirt

  • 156
  • 16
  • 7
  • 3
  • 1
Kaninchen

Klonalität

  • 155
  • 27
Polyklonal

Konjugat

  • 97
  • 29
  • 10
  • 10
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CA2 Antikörper ist unkonjugiert

Applikation

  • 148
  • 95
  • 54
  • 45
  • 40
  • 16
  • 13
  • 13
  • 11
  • 8
  • 8
  • 8
  • 3
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 31
    • 16
    • 9
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-260

    Verwendungszweck

    Anti-Carbonic Anhydrase II/CA2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Carbonic Anhydrase II/CA2 Antibody Picoband® (ABIN4886493). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human CA2 recombinant protein (Position: S2-K260). Human CA2 shares 81.1% and 80.7% amino acid (aa) sequence identity with mouse and rat CA2, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Aramaki, S., Yoshida, I., Yoshino, M., Kondo, M., Sato, Y., Noda, K., Jo, R., Okue, A., Sai, N., Yamashita, F. Carbonic anhydrase II deficiency in three unrelated Japanese patients. J. Inherit. Metab. Dis. 16: 982-990, 1993. 2. Laitala, T., Vaananen, H. K. Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase. J. Clin. Invest. 93: 2311-2318, 1994. 3. Venta, P. J., Welty, R. J., Johnson, T. M., Sly, W. S., Tashian, R. E. Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107his-to-tyr): complete structure of the normal human CA II gene. Am. J. Hum. Genet. 49: 1082-1090, 1991.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    CA2 (Carbonic Anhydrase II (CA2))

    Andere Bezeichnung

    CA2

    Hintergrund

    Synonyms: Carbonic anhydrase 2,4.2.1.1,Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II,CA2,

    Tissue Specificity: Ubiquitous, with higher levels in heart, substantia nigra, and kidney. .

    Background: CA2 is a cytosolic enzyme with the highest activity among all known CAs. The carbonic anhydrases (ACs) form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs relatively slowly in the absence of a catalyst. Mutations in the CA2 gene result in the CA II deficiency syndrome, an autosomal recessive disorder that produces osteopetrosis, renal tubular acidosis and cerebral calcification. This gene is mapped to 8q22.

    Molekulargewicht

    29 kDa

    Gen-ID

    760

    UniProt

    P00918
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