CCR4 Antikörper (C-Term)

Produktnummer ABIN488046

Der Kaninchen Polyklonal anti-CCR4 Antikörper (ABIN488046) detektiert spezifisch CCR4 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CCR4 Antikörper (C-Term) (ABIN488046)

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CCR4 Antikörper

Bindungsspezifität: C-Term

Spezifität: Recognizes C-C Chemokine Receptor 4 (CCR4/CD194).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide – KLH conjugated. Epitope: C-terminal domain of Human.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer.

Details zu CCR4

Target: CCR4 (Chemokine (C-C Motif) Receptor 4 (CCR4))

Andere Bezeichnung: CD194 / CCR4

Hintergrund: Receptors for the C - C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5 and the Duffy blood group antigen. The C - C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR4 is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. CCR4 mediates inflammatory responses and HIV-1 infections. It binds beta-family chemokines (CC motif) such as TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derived chemokine).Synonyms: C-C CKR-4, C-C chemokine receptor type 4, CC-CKR-4, CCR-4, CMKBR4, K5-5

Gen-ID: 4887

NCBI Accession: NP_000901

UniProt: P51679