PLA2R1 Antikörper (Internal Region)

Produktnummer ABIN487965

Produktdetails anti-PLA2R1 Antikörper

Target: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PLA2R1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: c-EKKKDTPKQH GT

Spezifität: This antibody is expected to recognize all reported isoforms (NP_031392.3, NP_001007268.1, NP_001182570.1) of PLA2R1.

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog), Pig.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the Internal region of the protein sequence according to NP_031392.3, NP_001007268.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/64000. Western blot: Approx 140 kDa band observed in Human Ileum lysates (calculated MW of150 kDa according to NP_001007268.1). Recommended concentration: 1 - 3 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PLA2R1

Target: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Andere Bezeichnung: PLA2R1 / PLA2R (PLA2R1 Produkte)

Synonyme: Pla2-r antikoerper, Pla2g1br antikoerper, Pla2r antikoerper, CLEC13C antikoerper, PLA2-R antikoerper, PLA2G1R antikoerper, PLA2IR antikoerper, PLA2R antikoerper, phospholipase A2 receptor 1 antikoerper, PLA2R1 antikoerper, Pla2r1 antikoerper

Hintergrund: PLA2R is a receptor for secretory phospholipase A2 (sPLA2). It acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. PLA2R may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.Synonyms: 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, CLEC13C, M-type receptor, PLA2-R, Secretory phospholipase A2 receptor

Gen-ID: 22925

NCBI Accession: NP_001007268

UniProt: Q13018

Pathways: Positive Regulation of Response to DNA Damage Stimulus