FOXP3 Antikörper

Produktnummer ABIN487427

Der Maus Monoklonal anti-FOXP3 Antikörper wird verwendet zum Nachweis von FOXP3 in Proben von Human und Maus. Er wurde validiert für WB und FACS.

Kurzübersicht für FOXP3 Antikörper (ABIN487427)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: 3G3

Produktdetails anti-FOXP3 Antikörper

Spezifität: The mouse monoclonal antibody 3G3 recognizes N-terminal region of FoxP3, a 47-55 kDa transcription factor, which is the master regulator in the development and function of regulatory T cells.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Produktmerkmale: Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

Aufreinigung: Protein A affinity chromatography

Immunogen: Full-length His-tagged recombinant murine FoxP3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry (Application note see below). Western blot: 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: FOXP3

Hintergrund: FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

Gen-ID: 20371

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation