Sphingomyelin Synthase 1 Antikörper

Produktnummer ABIN4620352

Produktdetails anti-Sphingomyelin Synthase 1 Antikörper

Target: Sphingomyelin Synthase 1 (SGMS1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sphingomyelin Synthase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Sphingomyelin Synthase 1, expressed in brain, heart, kidney, liver, muscle and stomach.

Aufreinigung: Ligand Affinity Chromatography

Immunogen: Synthetic peptide derived from the Human Sphingomyelin Synthase 1 protein

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: (5-10 g). Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Sphingomyelin Synthase 1

Target: Sphingomyelin Synthase 1 (SGMS1)

Andere Bezeichnung: TMEM23 / SGMS1 (SGMS1 Produkte)

Hintergrund: A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus, Golgi membrane, multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.Synonyms: MOB, Medulla oblongata-derived protein, Phosphatidylcholine:ceramide cholinephosphotransferase 1, SMS1, Sphingomyelin synthase 1, Transmembrane protein 23

Gen-ID: 259230

NCBI Accession: NP_671512

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin