CRYAB Antikörper

Produktnummer ABIN453950

Produktdetails anti-CRYAB Antikörper

Target: CRYAB (Crystallin, alpha B (CRYAB))

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRYAB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects a band at ~20 kDa corresponding to Alpha B Crystallin. Does not cross react with Alpha A Crystallin, Beta-L Crystallin, Beta-H Crystallin, Gamma Crystallin, Hsp25, Hsp27 or Hsp47 proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Bovine.

Produktmerkmale: Synonyms: Alpha(B)-crystallin, CRYAB, CRYA2, Heat shock protein beta-5, Renal carcinoma antigenNY-REN-27, HspB5, Rosenthal fiber component

Aufreinigung: Protein G Affinity Chromatography

Immunogen: Native alpha B crystallin

Klon: 1A7-D5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot (10): 1/2000. ELISA.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS pH 7.2, 0.09 % Sodium Azide, 50 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CRYAB

Target: CRYAB (Crystallin, alpha B (CRYAB))

Andere Bezeichnung: alpha-Crystallin B Chain (CRYAB Produkte)

Synonyme: CMD1II antikoerper, CRYA2 antikoerper, CTPP2 antikoerper, CTRCT16 antikoerper, HSPB5 antikoerper, MFM2 antikoerper, Crya-2 antikoerper, Crya2 antikoerper, HspB5 antikoerper, AACRYA antikoerper, CRYAB antikoerper, cryab antikoerper, cryab2 antikoerper, wu:fe37f08 antikoerper, zgc:91937 antikoerper, crystallin alpha B antikoerper, crystallin, alpha B antikoerper, hypothetical protein antikoerper, crystallin, alpha B, a antikoerper, crystallin, alpha B, b antikoerper, CRYAB antikoerper, Cryab antikoerper, ZK1128.7 antikoerper, cryaba antikoerper, cryabb antikoerper

Hintergrund: The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alphacrystallins possess structural and functional imilarities with Hsp25 and Hsp27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).Synonyms: Alpha(B)-crystallin, CRYA2, CRYAB, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component

Molekulargewicht: approx. 21 kDa (Predicted)

Gen-ID: 1410

UniProt: P02511