MTA2 Antikörper (C-Term)

Produktnummer ABIN453277

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MTA2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MTA2 Antikörper (C-Term) (ABIN453277)

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-MTA2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to MTA2.

Aufreinigung: Saturated Ammonium Sulfate (SAS) precipitation

Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human MTA2

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MTA2

Target: MTA2 (Metastasis Associated 1 Family, Member 2 (MTA2))

Andere Bezeichnung: MTA2

Hintergrund: MTA2 is a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small family of different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex

Gen-ID: 9219

NCBI Accession: NP_004730

UniProt: O94776

Pathways: Chromatin Binding