FOXE1 Antikörper (C-Term)

Produktnummer ABIN452689

Dieser Ziege Polyklonal Antikörper detektiert spezifisch FOXE1 in IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FOXE1 Antikörper (C-Term) (ABIN452689)

Target: FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser FOXE1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-FOXE1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Recognizes FOXE1 / TTF2 at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):Bat, Elephant, Marmoset, Gorilla, Monkey, Rabbit.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-AYPGGIDRFVSAM, from the C Terminus of the protein sequence according to NP_004464.2. Genename: FOXE1

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit Dilution: 1/32000. Western blot: Preliminary experiments gave an approx 70 kDa band in Human Thymus andThyroid Gland lysates after 0.3 μg/mL antibody staining. Please note that currently wecannot find an explanation in the literature for the band we observe given the calculated

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu FOXE1

Target: FOXE1 (Forkhead Box E1 (Thyroid Transcription Factor 2) (FOXE1))

Andere Bezeichnung: FOXE1 / FKHL15

Hintergrund: Forkhead box protein E1 (FOXE1) is a member of the forkhead/ winged-helix domain transcription factor family. FOXE1, also designated FKHL15 or TTF-2, complexes with TTF-1 and Pax-8 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of the sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). FOXE1 encodes a protein that is expressed in several tissues, including thymus, adult brain, lung, liver, heart and pancreas. The chromosomal location of the FOXE1 gene on 9q22 suggests that it may be involved in squamous cell epithelioma and hereditary sensory neuropathy type I. Mutations in the FOXE1 gene lead to the development of congenital hypothyroidism, which occurs in approximately one in four thousand newborns and results in complete or partial failure of thyroid gland development. Patients who are homozygous for a missense mutation in the forkhead domain of he FOXE1 gene can also develop thyroid agenesis, cleft palate and choanal atresia. Subsequently, the FOXE1 gene may used as a marker to study these disorders.Synonyms: FOXE2, Forkhead box protein E1, HFKH4, HFKL5, HNF-3/fork head-like protein 5, TITF2, TTF-2, TTF2, Thyroid transcription factor 2

Gen-ID: 2304

NCBI Accession: NP_004464

UniProt: O00358