TYMS Antikörper (N-Term)

Produktnummer ABIN452662

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TYMS in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TYMS Antikörper (N-Term) (ABIN452662)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TYMS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Klon: AT1S5

Produktdetails anti-TYMS Antikörper

Bindungsspezifität: AA 1-313, N-Term

Spezifität: The antibody recognizes human TYMS. Other species not tested.

Produktmerkmale: Synonyms: TYMS, TSase, OK/SW-cl.29

Aufreinigung: Protein-G affinity chromatography

Immunogen: Recombinant TYMS (1-313 aa) purified from E. coli

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot (1: 500 - 1: 1,000). Immunofluorescence (1: 500 - 1: 1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for up to two weeks or (in aliquots) at -20 °C or -70 °Cfor longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Andere Bezeichnung: Thymidylate Synthase (TS)

Hintergrund: The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dMTP) is an essential step for the formation of thymine nucleotides. This process is catalyzed by thymidylate synthase (TS or TYMS). TYMS is an intracellular enzyme that provides the sole de novo source of thymidylate in activity highest proliferating cells. Being the exclusive source of dTMP, TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head and neck. TS expression may be useful in predicting overall patient survival, but the prognostic value of TS expression continues to be a subject of investigation for different types of cancers.Synonyms: OK/SW-cl.29, TSase, TYMS

Gen-ID: 54583

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases