KDELR1 Antikörper

Produktnummer ABIN452265

Der Maus Monoklonal anti-KDELR1 Antikörper (Klon KR-10) (ABIN452265) detektiert spezifisch KDELR1 in WB, IF, IP und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Diverse Spezies.

Kurzübersicht für KDELR1 Antikörper (ABIN452265)

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Reaktivität: Diverse Spezies

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KDELR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: KR-10

Produktdetails anti-KDELR1 Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human, Monkey, Mouse, Rat, Hamster, Rabbit, Pig, Bovine, Sheep, Canine, Chicken, Drosphilia, Xenopus

Produktmerkmale: Synonyms: KDEL endoplasmic reticulum protein retention receptor 1, ERD2.1, ER marker, ER lumenprotein retaining receptor 1, Putative MAPK-activating protein PM23

Aufreinigung: Protein G chromatography

Immunogen: A 21 residue synthetic peptide based on the bovine KDEL receptor and the peptide coupledto KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunoprecipitation (1). Immunocytochemistry (3). Immunohistochemisztry on frozen sections. Western blot (2).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS pH 7.2, in 50 % glycerol with 0.09 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu KDELR1

Target: KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))

Andere Bezeichnung: KDEL Receptor 1 / KDELR1

Hintergrund: The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). However, variation on KDEL does occur and other sequences can also give rise to endoplasmic reticulum retention (6). There are three KDEL receptors in mammalian cells, all have a very high degree of sequence identity, and all are located within the cis-Golgi and its intermediate compartments (4). In terms of function, KDEL receptors interact with GAP (GTPase-activating protein) of ARF1, which is involved in COPI dependent vesicle transport, and the KDEL receptor may also be responsible for the recruitment of this ARF1 to membranes which can then aid in the regulation of vesicle budding (3). It is also important to note that the KDEL receptor exhibits extensive sequence identity o yeast protein Erd2p, which is a receptor for the yeast ER retention signal (4, 5).Synonyms: ER lumen protein retaining receptor 1, ER marker, ERD2.1, KDEL endoplasmic reticulum protein retention receptor 1, Putative MAPK-activating protein PM23

Gen-ID: 618184

UniProt: P33946

Pathways: Maintenance of Protein Location