PML Antikörper
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- Target Alle PML Antikörper anzeigen
- PML (Promyelocytic Leukemia (PML))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser PML Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- This antibody recognizes normal PML proteins of lower Molecular Weight, and also recognizes the High Molecular Weight PML/RAR-alpha Chimeric protein in promyelocytic leukemia patients.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human.
- Produktmerkmale
- Synonyms: RING finger protein 71, MYL, TRIM19, Probable transcription factor PML, Tripartitemotif-containing protein 19
- Aufreinigung
- Affinity Chromatography on Protein G.
- Immunogen
- Recombinant partial Human PML.
- Klon
- B3E9
- Isotyp
- IgG1
- Top Product
- Discover our top product PML Primärantikörper
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- Applikationshinweise
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Western Blot: Use PML antibody at 1/2,000 dilution to differentiate normal PML andChimeric PML/RAR alpha molecules based on their molecular weight.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Rekonstitution
- Restore by adding appropriate volume of distilled water to reach a final antibody concentration of 1.0 mg/mL.
- Buffer
- 0.01 M PBS, pH 7.4 without preservatives.
- Konservierungsmittel
- Without preservative
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
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Store the antibody (in aliquots) at -20 °C. After reconstitution, aliquot and store at -20 °C.
Shelf life: one year from despatch. - Haltbarkeit
- 12 months
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- Target
- PML (Promyelocytic Leukemia (PML))
- Andere Bezeichnung
- PML / RNF71 (PML Produkte)
- Synonyme
- MYL antikoerper, PP8675 antikoerper, RNF71 antikoerper, TRIM19 antikoerper, 1200009E24Rik antikoerper, AI661194 antikoerper, Trim19 antikoerper, RGD1562602 antikoerper, PML antikoerper, promyelocytic leukemia antikoerper, PML antikoerper, Pml antikoerper
- Hintergrund
- PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.Synonyms: MYL, Probable transcription factor PML, RING finger protein 71, TRIM19, Tripartite motif-containing protein 19
- Gen-ID
- 5371
- UniProt
- P29590
- Pathways
- p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus
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