PML Antikörper

Produktnummer ABIN452172

Dieses Anti-PML-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PML in WB. Geeignet für Human.

Kurzübersicht für PML Antikörper (ABIN452172)

Target: PML (Promyelocytic Leukemia (PML))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PML Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: B3E9

Produktdetails anti-PML Antikörper

Spezifität: This antibody recognizes normal PML proteins of lower Molecular Weight, and also recognizes the High Molecular Weight PML/RAR-alpha Chimeric protein in promyelocytic leukemia patients.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Produktmerkmale: Synonyms: RING finger protein 71, MYL, TRIM19, Probable transcription factor PML, Tripartitemotif-containing protein 19

Aufreinigung: Affinity Chromatography on Protein G.

Immunogen: Recombinant partial Human PML.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: Use PML antibody at 1/2,000 dilution to differentiate normal PML andChimeric PML/RAR alpha molecules based on their molecular weight.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore by adding appropriate volume of distilled water to reach a final antibody concentration of 1.0 mg/mL.

Buffer: 0.01 M PBS, pH 7.4 without preservatives.

Konservierungsmittel: Without preservative

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C. After reconstitution, aliquot and store at -20 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu PML

Target: PML (Promyelocytic Leukemia (PML))

Andere Bezeichnung: PML / RNF71

Hintergrund: PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.Synonyms: MYL, Probable transcription factor PML, RING finger protein 71, TRIM19, Tripartite motif-containing protein 19

Gen-ID: 5371

UniProt: P29590

Pathways: p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus