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GRIN2B Antikörper (pTyr1474)

GRIN2B Reaktivität: Human, Ratte, Maus IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401598
  • Target Alle GRIN2B Antikörper anzeigen
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Bindungsspezifität
    • 33
    • 30
    • 24
    • 23
    • 22
    • 20
    • 16
    • 10
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1474
    Reaktivität
    • 197
    • 183
    • 154
    • 30
    • 27
    • 24
    • 10
    • 10
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 205
    • 40
    • 1
    Kaninchen
    Klonalität
    • 207
    • 39
    Polyklonal
    Konjugat
    • 109
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser GRIN2B Antikörper ist unkonjugiert
    Applikation
    • 199
    • 68
    • 65
    • 65
    • 46
    • 43
    • 34
    • 24
    • 24
    • 18
    • 16
    • 11
    • 10
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (IF)
    Spezifität
    NMDAR2B (phospho-Tyr1474) antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1474.
    Aufreinigung
    Affinity-chromatography
    Immunogen
    Synthesized phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1474 (H-V-YP-E-K)
    Top Product
    Discover our top product GRIN2B Primärantikörper
  • Applikationshinweise
    Immunofluorescence: 1/100 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
  • Target
    GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))
    Andere Bezeichnung
    NMDAR2B (GRIN2B Produkte)
    Synonyme
    NMDAR2B antikoerper, GluN2B antikoerper, MRD6 antikoerper, NR2B antikoerper, hNR3 antikoerper, nmdar2b antikoerper, nr2b antikoerper, AW490526 antikoerper, Nmdar2b antikoerper, glutamate ionotropic receptor NMDA type subunit 2B antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 2B L homeolog antikoerper, glutamate receptor, ionotropic, NMDA2B (epsilon 2) antikoerper, GRIN2B antikoerper, Grin2b antikoerper, grin2b.L antikoerper
    Hintergrund
    NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain types of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.Synonyms: GRIN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA Receptor 2B
    Gen-ID
    2904
    NCBI Accession
    NP_000825
    UniProt
    Q13224
    Pathways
    Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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