HMOX2 Antikörper (Internal Region)

Produktnummer ABIN401519

Produktdetails anti-HMOX2 Antikörper

Target: HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser HMOX2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: c-DQAGSTLARE TLED

Spezifität: This antibody detects HMOX2 (Internal).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from the internal region of the protein sequence according to NP_002125.3 . Genename: HMOX2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: antibody detection limit dilution 1: 32000. Western blot: Recommended concentration: 0.3-1 μg/mL. Approx 37 kDa band observed inlysates of cell line K562 (calculated MW of 36.7 kDa according to NP_002125.3).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Details zu HMOX2

Target: HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))

Andere Bezeichnung: Heme Oxygenase 2 (HMOX2) (HMOX2 Produkte)

Synonyme: HO-2 antikoerper, HO2 antikoerper, HMOX2 antikoerper, Ho-2 antikoerper, im:6909100 antikoerper, si:dkey-44g23.7 antikoerper, AtHO2 antikoerper, T9J22.22 antikoerper, T9J22_22 antikoerper, heme oxygenase 2 antikoerper, hmox2 antikoerper, ho-2 antikoerper, heme oxygenase 2 antikoerper, Heme oxygenase 2 antikoerper, heme oxygenase 2, putative antikoerper, heme oxygenase 2a antikoerper, heme oxygenase 2 L homeolog antikoerper, HMOX2 antikoerper, Hmox2 antikoerper, HO2 antikoerper, ho2 antikoerper, CNF01200 antikoerper, CPR_0203 antikoerper, CGB_F5120W antikoerper, hmox2a antikoerper, hmox2.L antikoerper

Hintergrund: Heme oxygenase (HO) is a microsomal enzyme involved in cellular response to oxidative stress. HO oxidatively cleaves the heme ring at the alpha methene bridge to form carbon monoxide and biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Two heme oxygenase isozymes, termed HO 1 and HO 2, have been identified so far. At the amino acid level, HO 1 and HO 2 are 42 % homologous. However, each isozyme is evolutionary highly conserved. HO 1 is the inducible form of the enzyme and is therefore also referred to as stress protein Hsp32. Expression of HO 1 can be induced by a variety of stimuli such as heme, metals, hormones, UV radiation and sulfhydryl depleting agents. In contrast, HO 2 is the constituitive form of the enzyme. It is not inducible by exogeneous stimuli and HO 2 is the most prevalent form in most tissues, except the spleen where HO 1 levels are predominant under normal conditions.Synonyms: HO-2, HO2

Gen-ID: 3163

NCBI Accession: NP_002125

UniProt: P30519

Pathways: Transition Metal Ion Homeostasis