PTENP1 Antikörper (N-Term)

Produktnummer ABIN401437

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PTENP1 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Schimpanse, Hund, Makake, Maus, Ratte, Grüner Kugelfisch und Zebrafisch (Danio rerio).

Kurzübersicht für PTENP1 Antikörper (N-Term) (ABIN401437)

Target: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Reaktivität: Human, Schimpanse, Hund, Makake, Maus, Ratte, Grüner Kugelfisch, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTENP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PTENP1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine, Macaque, Chimpanzee, Opossum, Zebrafish, Green pufferfish, Platypus.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Purified peptide corresponding to amino acids near the N-terminal end of human PTEN-P1 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/160,000. Western Blot: 1/500 to 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.73 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu PTENP1

Target: PTENP1 (Phosphatase and Tensin Homolog Pseudogene 1 (PTENP1))

Andere Bezeichnung: PTENP1

Hintergrund: This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.Synonyms: PTEN-rs, PTEN2, PTH2, Phosphatase and tensin homolog 2, Phosphatase and tensin homolog pseudogene 1, psiPTEN

Gen-ID: 9606

UniProt: O43460