CRTC1 Antikörper (AA 19-34)

Produktnummer ABIN401346

Der Kaninchen Polyklonal anti-CRTC1 Antikörper (ABIN401346) detektiert spezifisch CRTC1 in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh) und Zebrafisch (Danio rerio).

Kurzübersicht für CRTC1 Antikörper (AA 19-34) (ABIN401346)

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-CRTC1 Antikörper

Bindungsspezifität: AA 19-34

Spezifität: This antibody is directed against MECT1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Zebrafish, Pufferfish, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to amino acids 19-34 of human MECT1 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10,000 - 1/40,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.95 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: CRTC1 / MECT1

Hintergrund: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response elementbinding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.Synonyms: CREB-regulated transcription coactivator 1, KIAA0616, Mucoepidermoid carcinoma translocated protein 1, TORC1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1

Gen-ID: 23373

NCBI Accession: NP_001091952

UniProt: Q6UUV9