CBLC Antikörper (AA 444-458)

Produktnummer ABIN401316

Der Kaninchen Polyklonal anti-CBLC Antikörper (ABIN401316) detektiert spezifisch CBLC in WB, IHC (p), IP und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Schimpanse.

Kurzübersicht für CBLC Antikörper (AA 444-458) (ABIN401316)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Reaktivität: Human, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Produktdetails anti-CBLC Antikörper

Bindungsspezifität: AA 444-458

Spezifität: This antibody is directed against Cbl-c protein. No reactivity is expected with Cbl-a or Cbl-b.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human, Chimpanzee.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to amino acids 444-458 of Human Cbl-c

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunoprecipitation. ELISA: 1/10,000 - 1/50,000. Western Blot: 1/500 - 1/3,000. Immunohistochemistry: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.42 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Andere Bezeichnung: CBLC / RNF57

Hintergrund: Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.Synonyms: CBL-3, CBL-C, CBL3, RING finger protein 57, SH3-binding protein CBL-C, Signal transduction protein CBL-C

Gen-ID: 23624

NCBI Accession: NP_001124324

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway