This antibody is directed against Mouse ZIC2 protein. A BLAST analysis was used to suggest reactivity with this protein from Human, Chimpanzee, Mouse, Rat and Dog based on 100 % homology for the immunogen sequence. Expect cross reactivity with ZIC2 from Chicken, Zebrafish and Frog as the core 16 amino acid residues within the immunogen sequence show very high degrees of homology with ZIC2 from these sources. Cross reactivity with ZIC2 homologues from other sources has not been determined.
Kreuzreaktivität (Details)
Species reactivity (expected):Human, Chimpanzee, Mouse, Rat, Canine, Chicken, Zebrafish, Frog. Species reactivity (tested):Mouse.
Aufreinigung
Affinity Chromatography
Immunogen
Synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2
ELISA: 1/10,000 - 1/50,000. Western Blot: 1/500 - 1/2,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
1.0 mg/mL (by UV absorbance at 280 nm)
Buffer
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
HPE5 antikoerper, Ku antikoerper, cb851 antikoerper, fb26a03 antikoerper, wu:fb26a03 antikoerper, zic2 antikoerper, zic2.1 antikoerper, hpe5 antikoerper, hm:zeh0655 antikoerper, id:ibd5017 antikoerper, zic2.2 antikoerper, zic2l antikoerper, Zic family member 2 antikoerper, zinc finger protein of the cerebellum 2 antikoerper, zic family member 2 (odd-paired homolog, Drosophila), a antikoerper, Zic family member 2 L homeolog antikoerper, zic family member 2 (odd-paired homolog, Drosophila) b antikoerper, ZIC2 antikoerper, Zic2 antikoerper, zic2a antikoerper, zic2.L antikoerper, zic2b antikoerper
Hintergrund
ZIC2 (also known as zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.Synonyms: Zinc finger protein ZIC 2, Zinc finger protein of the cerebellum 2