CD28 Antikörper

Produktnummer ABIN400890

Dieses Anti-CD28-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD28 in FACS, WB, IF, IP, Func und IHC (fro). Geeignet für Human und Primate.

Kurzübersicht für CD28 Antikörper (ABIN400890)

Target: CD28

Reaktivität: Human, Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD28 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: CD28-2

Produktdetails anti-CD28 Antikörper

Spezifität: The antibody reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.

Produktmerkmale: Synonyms: TP44, T-cell-specific surface glycoprotein CD28

Aufreinigung: Affinity Chromatography on Protein A

Sterilität: 0.2 μm filtered

Immunogen: DC28. 1. 3. 3 hybridoma cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry on frozen sections. Immunoflourescence. Functional Application. T cell costimulation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Azide free Phosphate Buffered Saline (PBS), pH ~7.4, 0.2 μm filter sterilization. Endotoxin level is less than 10 EU/mg of the protein, as determined by the LAL test.

Konservierungsmittel: Azide free

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing andthawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD28

Target: CD28

Andere Bezeichnung: CD28

Hintergrund: CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.Synonyms: T-cell-specific surface glycoprotein CD28, TP44

Gen-ID: 940

UniProt: P10747

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response