SIK2 Antikörper

Produktnummer ABIN400680

Dieses Anti-SIK2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SIK2 in WB, IP, IF, ICC und IHC (p). Geeignet für Human.

Kurzübersicht für SIK2 Antikörper (ABIN400680)

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: S15G10

Produktdetails anti-SIK2 Antikörper

Produktmerkmale: Synonyms: SIK-2, SNF1LK2, QIK, Serine/threonine-protein kinase SIK2, Salt-inducible protein kinase 2,Serine/threonine-protein kinase SNF1-like kinase 2, Qin-induced kinase

Aufreinigung: Affinity Chromatography.

Immunogen: Recombinant Human SIK2.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot. Immunoprecipitation. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.2 containing 0.09% Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu SIK2

Target: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Andere Bezeichnung: SIK2

Hintergrund: Snf1lk2 belongs to the Ser/Thr protein kinase family, AMPK subfamily. It has one proteinkinase domain and one UBA domain. Snf1lk2 requires magnesium as a cofactor andphosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes. This potentiallymodulates the efficiency of insulin signal transduction. It also inhibits CREB activity byphosphorylating and repressing the CREB-specific coactivators, CRTC1-3. Snf1lk2 isactivated by phosphorylation on Thr-175 by STK11 in complex with STE20-relatedadapter-alpha (STRAD alpha) pseudo kinase and CAB39.

UniProt: Q9H0K1