Adenylate Kinase 5 Antikörper (N-Term)

Produktnummer ABIN392733

Produktdetails anti-Adenylate Kinase 5 Antikörper

Target: Adenylate Kinase 5 (AK5)

Bindungsspezifität: AA 404-433, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Adenylate Kinase 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This AK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-433 amino acids from the N-terminal region of human AK5.

Klon: RB3883

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Adenylate Kinase 5 Antikörper (ABIN392733)

Saito, Kitamura, Hijikata, Tomizawa-Murasawa, Tanaka, Takagi, Uchida, Suzuki, Sone, Najima, Ozawa, Wake, Taniguchi, Shultz, Ohara, Ishikawa: "Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells." in: Science translational medicine, Vol. 2, Issue 17, pp. 17ra9, (2010) (PubMed).

Details zu Adenylate Kinase 5

Target: Adenylate Kinase 5 (AK5)

Andere Bezeichnung: AK5 (AK5 Produkte)

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Molekulargewicht: 63333

Gen-ID: 26289

NCBI Accession: NP_036225, NP_777283

UniProt: Q9Y6K8

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process