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UHMK1 Antikörper (N-Term)

UHMK1 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB3367 unconjugated
Produktnummer ABIN392641
  • Target Alle UHMK1 Antikörper anzeigen
    UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))
    Bindungsspezifität
    • 19
    • 15
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reaktivität
    • 32
    • 30
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 51
    • 6
    • 1
    Kaninchen
    Klonalität
    • 53
    • 5
    Polyklonal
    Konjugat
    • 18
    • 6
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UHMK1 Antikörper ist unkonjugiert
    Applikation
    • 45
    • 29
    • 13
    • 13
    • 12
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KIST (KIS).
    Klon
    RB3367
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Chen, Xie, Gu, Cai, Wang, Xie, Dong, He, Zhong, Lin, Huang: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." in: Scientific reports, Vol. 5, pp. 8293, (2015) (PubMed).

    Lee, Kay: "PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2." in: Investigative ophthalmology & visual science, Vol. 52, Issue 1, pp. 417-26, (2011) (PubMed).

    Nakamura, Yamashita, Yokota, Hirano, Ono, Fujie, Shibata, Niimi, Suyama, Maddali, Asai, Yamashita, Iguchi, Ohnishi: "Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity." in: Investigational new drugs, Vol. 28, Issue 4, pp. 381-91, (2010) (PubMed).

    Takemura, Nakamura, Yokota, Hirano, Ono, Shigeno, Fujisawa, Ohnishi: "Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6585-94, (2010) (PubMed).

    Nakamura, Hirano, Okinaka, Takemura, Yokota, Ono, Shigeno, Shibata, Fujisawa, Ohnishi: "The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia." in: Carcinogenesis, Vol. 31, Issue 11, pp. 2012-21, (2010) (PubMed).

    Petrovic, Costa, Lau, Raychaudhuri, Tyner: "FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression." in: The Journal of biological chemistry, Vol. 283, Issue 1, pp. 453-60, (2007) (PubMed).

  • Target
    UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))
    Andere Bezeichnung
    KIST (KIS) (UHMK1 Produkte)
    Synonyme
    UHMK1 antikoerper, zgc:153241 antikoerper, KIS antikoerper, KIST antikoerper, P-CIP2 antikoerper, 4732477C12Rik antikoerper, 4930500M09Rik antikoerper, AA673513 antikoerper, AI449218 antikoerper, AU021979 antikoerper, Kist antikoerper, U2AF homology motif kinase 1 antikoerper, U2AF homology motif (UHM) kinase 1 antikoerper, UHMK1 antikoerper, uhmk1 antikoerper, Uhmk1 antikoerper
    Hintergrund
    Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
    Molekulargewicht
    46546
    Gen-ID
    127933
    NCBI Accession
    NP_001171692, NP_653225, NP_787062
    UniProt
    Q8TAS1
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