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UHMK1 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch UHMK1 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 6+ Publikationen erwähnt.
Produktnummer ABIN392641

Kurzübersicht für UHMK1 Antikörper (N-Term) (ABIN392641)

Target

Alle UHMK1 Antikörper anzeigen
UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))

Reaktivität

  • 33
  • 26
  • 25
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus

Wirt

  • 47
  • 6
  • 1
Kaninchen

Klonalität

  • 49
  • 5
Polyklonal

Konjugat

  • 19
  • 5
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser UHMK1 Antikörper ist unkonjugiert

Applikation

  • 41
  • 25
  • 13
  • 13
  • 13
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB3367
  • Bindungsspezifität

    • 15
    • 14
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 1-30, N-Term

    Homologie

    Rat

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KIST (KIS).

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Chen, Xie, Gu, Cai, Wang, Xie, Dong, He, Zhong, Lin, Huang: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." in: Scientific reports, Vol. 5, pp. 8293, (2015) (PubMed).

    Lee, Kay: "PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2." in: Investigative ophthalmology & visual science, Vol. 52, Issue 1, pp. 417-26, (2011) (PubMed).

    Nakamura, Yamashita, Yokota, Hirano, Ono, Fujie, Shibata, Niimi, Suyama, Maddali, Asai, Yamashita, Iguchi, Ohnishi: "Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity." in: Investigational new drugs, Vol. 28, Issue 4, pp. 381-91, (2010) (PubMed).

    Takemura, Nakamura, Yokota, Hirano, Ono, Shigeno, Fujisawa, Ohnishi: "Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6585-94, (2010) (PubMed).

    Nakamura, Hirano, Okinaka, Takemura, Yokota, Ono, Shigeno, Shibata, Fujisawa, Ohnishi: "The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia." in: Carcinogenesis, Vol. 31, Issue 11, pp. 2012-21, (2010) (PubMed).

    Petrovic, Costa, Lau, Raychaudhuri, Tyner: "FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression." in: The Journal of biological chemistry, Vol. 283, Issue 1, pp. 453-60, (2007) (PubMed).

  • Target

    UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))

    Andere Bezeichnung

    KIST (KIS)

    Hintergrund

    Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.

    Molekulargewicht

    46546

    Gen-ID

    127933

    NCBI Accession

    NP_001171692, NP_653225, NP_787062

    UniProt

    Q8TAS1
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