PLK3 Antikörper (C-Term)

Produktnummer ABIN392602

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PLK3 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 1 Publikation erwähnt.

Kurzübersicht für PLK3 Antikörper (C-Term) (ABIN392602)

Target: PLK3 (Polo-Like Kinase 3 (PLK3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB0875

Produktdetails anti-PLK3 Antikörper

Bindungsspezifität: AA 615-646, C-Term

Homologie: Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 615-646 amino acids from the C-terminal region of human PLK3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PLK3 Antikörper (ABIN392602)

Zhang, Shi, Paddon, Hampong, Dai, Pelech: "B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35726-34, (2004) (PubMed).

Details zu PLK3

Target: PLK3 (Polo-Like Kinase 3 (PLK3))

Andere Bezeichnung: PLK3

Hintergrund: CNK, a member of the CDC5/Polo subfamily of Ser/Thr protein kinases, is involved in regulating M phase functions during the cell cycle. It may also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein. This membrane-associated protein binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. This protein exhibits a short half-live. In cells of hematopoietic origin, CNK is strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Cytokine and cellular adhesion trigger CNK induction. CNK is thought to be phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis The protein contains 2 POLO box domains.

Molekulargewicht: 71629

Gen-ID: 1263

NCBI Accession: NP_004064

UniProt: Q9H4B4

Pathways: Regulation of long-term Neuronal Synaptic Plasticity