Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

STK39 Antikörper (AA 346-376)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STK39 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 4+ Publikationen erwähnt.
Produktnummer ABIN392497

Kurzübersicht für STK39 Antikörper (AA 346-376) (ABIN392497)

Target

Alle STK39 Antikörper anzeigen
STK39 (serine threonine Kinase 39 (STK39))

Reaktivität

  • 77
  • 43
  • 20
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 76
  • 8
  • 1
Kaninchen

Klonalität

  • 73
  • 12
Polyklonal

Konjugat

  • 56
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser STK39 Antikörper ist unkonjugiert

Applikation

  • 64
  • 44
  • 35
  • 12
  • 7
  • 7
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB03418
  • Bindungsspezifität

    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 346-376

    Homologie

    Rat

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This SPAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-376 amino acids from the Central region of human SPAK.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Yang, Cai, Zhou, Chen, Chen, Chen, Wang, Fang, Zhou: "STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy." in: PLoS ONE, Vol. 8, Issue 9, pp. e74614, (2013) (PubMed).

    Wang, OConnell, McArdle, Wade, Dorff, Shah, Shi, Pan, Rampersaud, Shen, Kim, Subramanya, Steinle, Parsa, Ober, Welling, Chakravarti, Weder, Cooper, Mitchell, Shuldiner, Chang: "From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 1, pp. 226-31, (2009) (PubMed).

    Smith, Smallwood, Altman, Liedtke: "PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 283, Issue 32, pp. 22147-56, (2008) (PubMed).

    Liedtke, Wang, Smallwood: "Role for protein phosphatase 2A in the regulation of Calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function." in: The Journal of biological chemistry, Vol. 280, Issue 27, pp. 25491-8, (2005) (PubMed).

  • Target

    STK39 (serine threonine Kinase 39 (STK39))

    Andere Bezeichnung

    SPAK

    Hintergrund

    SPAK is a serine/threonine kinase containing an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain, a nuclear localization signal, a consensus caspase cleavage recognition motif, and a C-terminal region. Northern blot analysis detects ubiquitous expression, most abundantly in brain and pancreas. SPAK can phosphorylate itself and an exogenous substrate in vitro. SPAK immunoprecipitates from transfected mammalian cells in a complex with another serine/threonine kinase that phosphorylates catalytically inactive SPAK. SPAK activates the p38 MAP kinase pathway in cotransfection assays. Full-length SPAK is expressed in the cytoplasm in transfected cells, while a mutant corresponding to caspase-cleaved STK39 localizes predominantly in the nucleus.

    Molekulargewicht

    59474

    Gen-ID

    27347

    NCBI Accession

    NP_037365

    UniProt

    Q9UEW8
Sie sind hier:
Chat with us!