PIM2 Antikörper (C-Term)

Produktnummer ABIN392442

This anti-PIM2 antibody (ABIN392442) is a Rabbit Polyclonal antibody detecting PIM2 in WB, IP, IHC (p). Suitable for Human.

Kurzübersicht für PIM2 Antikörper (C-Term) (ABIN392442)

Target: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB01288

Produktdetails anti-PIM2 Antikörper

Bindungsspezifität: AA 277-308, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-308 amino acids from the C-terminal region of human PIM2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IP: 1:50~100. WB: 1:1000. WB: 1:1000. WB: 1:2000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PIM2 Antikörper (ABIN392442)

Pogacic, Bullock, Fedorov, Filippakopoulos, Gasser, Biondi, Meyer-Monard, Knapp, Schwaller: "Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity." in: Cancer research, Vol. 67, Issue 14, pp. 6916-24, (2007) (PubMed).

Details zu PIM2

Target: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Andere Bezeichnung: PIM2

Hintergrund: Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases. Pim-2 is highly homologous to Pim-1 with similar oncogenic functions. Pim-2 overexpression promotes resistance to a host of apoptotic stimuli, its expression is negatively regulated by growth factor depletion. Increased levels of Pim-2 has also been observed in certain cancers.

Molekulargewicht: 34190

Gen-ID: 11040

NCBI Accession: NP_006866

UniProt: Q9P1W9