PIM1 Antikörper

Produktnummer ABIN392441

Der Kaninchen Polyklonal Anti-PIM1-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, PIM1 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PIM1 Antikörper (ABIN392441)

Target: PIM1 (Pim-1 Oncogene (PIM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB15686

Produktdetails anti-PIM1 Antikörper

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PIM1 antibody is generated from rabbits immunized with PIM1 recombinant protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PIM1 Antikörper (ABIN392441)

Xu, Xiong, Cao, Huang, Wang, You, Zhou, Zheng, Hu, Zhang, Zhao: "PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value." in: Journal of experimental & clinical cancer research : CR, Vol. 35, Issue 1, pp. 133, (2017) (PubMed).

Baron, Anastasi, Hyjek, Bies, Reddy, Dong, Joseph, Thirman, Wroblewski, Wolff, Baron: "PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 15, pp. 5735-9, (2012) (PubMed).

Details zu PIM1

Target: PIM1 (Pim-1 Oncogene (PIM1))

Andere Bezeichnung: PIM1

Hintergrund: PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.

Molekulargewicht: 35686

Gen-ID: 5292

NCBI Accession: NP_001230115, NP_002639

UniProt: P11309

Pathways: Glycosaminoglycan Metabolic Process