Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

MAP3K9 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAP3K9 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN392422

Kurzübersicht für MAP3K9 Antikörper (C-Term) (ABIN392422)

Target

Alle MAP3K9 Antikörper anzeigen
MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

Reaktivität

  • 73
  • 44
  • 25
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 72
  • 1
Kaninchen

Klonalität

  • 73
Polyklonal

Konjugat

  • 17
  • 7
  • 6
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
Dieser MAP3K9 Antikörper ist unkonjugiert

Applikation

  • 44
  • 39
  • 39
  • 30
  • 19
  • 15
  • 9
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB0983
  • Bindungsspezifität

    • 15
    • 15
    • 15
    • 8
    • 8
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1070-1104, C-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This MLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1104 amino acids from the C-terminal region of human MLK1.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Polesskaya, Cunningham, Francis, Luebke, Zhu, Collins, Vasilyeva, Sahler, Desmet, Gelbard, Maggirwar, Walton, Frisina, Dewhurst: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." in: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).

    Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).

    Strath, Georgopoulos, Kellam, Blair: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." in: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).

  • Target

    MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

    Andere Bezeichnung

    MLK1

    Hintergrund

    MLK1 is a MLK(MAP3K) type protein kinase. The catalytic domain of mixed-lineage kinases (MLKs) kinases have amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition to thee unusual nature of the kinase catalytic domains, MLK1 and MLK2 contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. MLK1 is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. MLK1 expression has been documented in human epithelial tumor cell lines of colonic, breast and esophageal origin.

    Molekulargewicht

    121895

    Gen-ID

    4293

    NCBI Accession

    NP_149132

    UniProt

    P80192
Sie sind hier:
Chat with us!