MAP3K9 Antikörper (C-Term)

Produktnummer ABIN392422

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAP3K9 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für MAP3K9 Antikörper (C-Term) (ABIN392422)

Target: MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB0983

Produktdetails anti-MAP3K9 Antikörper

Bindungsspezifität: AA 1070-1104, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1104 amino acids from the C-terminal region of human MLK1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MAP3K9 Antikörper (ABIN392422)

Polesskaya, Cunningham, Francis, Luebke, Zhu, Collins, Vasilyeva, Sahler, Desmet, Gelbard, Maggirwar, Walton, Frisina, Dewhurst: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." in: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).

Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).

Strath, Georgopoulos, Kellam, Blair: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." in: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).

Details zu MAP3K9

Target: MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

Andere Bezeichnung: MLK1

Hintergrund: MLK1 is a MLK(MAP3K) type protein kinase. The catalytic domain of mixed-lineage kinases (MLKs) kinases have amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition to thee unusual nature of the kinase catalytic domains, MLK1 and MLK2 contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. MLK1 is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. MLK1 expression has been documented in human epithelial tumor cell lines of colonic, breast and esophageal origin.

Molekulargewicht: 121895

Gen-ID: 4293

NCBI Accession: NP_149132

UniProt: P80192