ILK Antikörper (N-Term)

Produktnummer ABIN391993

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ILK in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für ILK Antikörper (N-Term) (ABIN391993)

Target: ILK (Integrin-Linked Kinase (ILK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ILK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB1668

Produktdetails anti-ILK Antikörper

Bindungsspezifität: AA 11-41, N-Term

Homologie: B, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ILK1/ILK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of mouse ILK1/ILK2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-ILK Antikörper (ABIN391993)

Schramm, Opitz, Thies, Seifert, Moch, Weder, Soltermann: "Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 37, Issue 3, pp. 566-72, (2010) (PubMed).

Samara, Laguinge, Jessup: "Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling." in: Cancer research, Vol. 67, Issue 10, pp. 4774-82, (2007) (PubMed).

Details zu ILK

Target: ILK (Integrin-Linked Kinase (ILK))

Andere Bezeichnung: ILK1/ILK2

Hintergrund: Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction.

Molekulargewicht: 51373

Gen-ID: 16202

NCBI Accession: NP_001155196, NP_034692

UniProt: O55222

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration