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Cullin 4A Antikörper (N-Term)

CUL4A Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB10557 unconjugated
Produktnummer ABIN391852
  • Target Alle Cullin 4A (CUL4A) Antikörper anzeigen
    Cullin 4A (CUL4A)
    Bindungsspezifität
    • 11
    • 8
    • 7
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 102-131, N-Term
    Reaktivität
    • 59
    • 28
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 53
    • 6
    Kaninchen
    Klonalität
    • 47
    • 12
    Polyklonal
    Konjugat
    • 31
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Cullin 4A Antikörper ist unkonjugiert
    Applikation
    • 37
    • 25
    • 9
    • 9
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Cullin 4A (CUL4A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-131 amino acids from the N-terminal region of human Cullin 4A (CUL4A).
    Klon
    RB10557
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CUL4A Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    Cullin 4A (CUL4A)
    Abstract
    CUL4A Produkte
    Synonyme
    zgc:64071 antikoerper, CUL4A antikoerper, 2810470J21Rik antikoerper, AW495282 antikoerper, RGD1563853 antikoerper, cullin 4A antikoerper, CUL4A antikoerper, cul4a antikoerper, Cul4a antikoerper
    Hintergrund
    CUL4a is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.
    Molekulargewicht
    87680
    Gen-ID
    8451
    NCBI Accession
    NP_001008895, NP_001265442, NP_003580
    UniProt
    Q13619
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