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MAPK15 Antikörper (N-Term)

MAPK15 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB12573 unconjugated
Produktnummer ABIN391796
  • Target Alle MAPK15 Antikörper anzeigen
    MAPK15 (Mitogen-Activated Protein Kinase 15 (MAPK15))
    Bindungsspezifität
    • 11
    • 10
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 32-61, N-Term
    Reaktivität
    • 52
    • 17
    • 3
    Human
    Wirt
    • 39
    • 13
    Kaninchen
    Klonalität
    • 41
    • 11
    Polyklonal
    Konjugat
    • 24
    • 6
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAPK15 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 36
    • 21
    • 13
    • 7
    • 6
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This MAPK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.
    Klon
    RB12573
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Groehler, Lannigan: "A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 575-86, (2010) (PubMed).

  • Target
    MAPK15 (Mitogen-Activated Protein Kinase 15 (MAPK15))
    Andere Bezeichnung
    MAPK15 (ERK8) (MAPK15 Produkte)
    Synonyme
    MGC138052 antikoerper, MGC99048 antikoerper, erk7 antikoerper, zgc:110345 antikoerper, ERK7 antikoerper, ERK8 antikoerper, BC048082 antikoerper, Erk7 antikoerper, ATMPK15 antikoerper, F25P22.9 antikoerper, F25P22_9 antikoerper, MAP kinase 15 antikoerper, mitogen-activated protein kinase 15 antikoerper, mitogen-activated protein kinase 15 L homeolog antikoerper, MAP kinase 15 antikoerper, MAPK15 antikoerper, mapk15.L antikoerper, mapk15 antikoerper, Tsp_00300 antikoerper, Mapk15 antikoerper, MPK15 antikoerper
    Hintergrund
    The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
    Molekulargewicht
    59832
    Gen-ID
    225689
    NCBI Accession
    NP_620590
    UniProt
    Q8TD08
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