MAPK15 Antikörper (N-Term)

Produktnummer ABIN391796

Der Kaninchen Polyklonal Anti-MAPK15-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, MAPK15 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für MAPK15 Antikörper (N-Term) (ABIN391796)

Target: MAPK15 (Mitogen-Activated Protein Kinase 15 (MAPK15))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB12573

Produktdetails anti-MAPK15 Antikörper

Bindungsspezifität: AA 32-61, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MAPK15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human MAPK15.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MAPK15 Antikörper (ABIN391796)

Groehler, Lannigan: "A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 575-86, (2010) (PubMed).

Details zu MAPK15

Target: MAPK15 (Mitogen-Activated Protein Kinase 15 (MAPK15))

Andere Bezeichnung: MAPK15 (ERK8)

Hintergrund: The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.

Molekulargewicht: 59832

Gen-ID: 225689

NCBI Accession: NP_620590

UniProt: Q8TD08