DYRK1B Antikörper (C-Term)

Produktnummer ABIN391774

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DYRK1B in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für DYRK1B Antikörper (C-Term) (ABIN391774)

Target: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DYRK1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3017

Produktdetails anti-DYRK1B Antikörper

Bindungsspezifität: AA 561-589, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This DYRK1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-589 amino acids from the C-terminal region of human DYRK1B.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-DYRK1B Antikörper (ABIN391774)

Gao, Zhao, Lv, Chen, Wei, Tian, Yang, Kong, Pang, Liu, Shi: "Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells." in: Cancer cell international, Vol. 13, Issue 1, pp. 2, (2013) (PubMed).

Gao, Yang, Yin, Hu, Liao, Miao, Pan, Li: "The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer." in: International journal of oncology, Vol. 40, Issue 4, pp. 1203-9, (2012) (PubMed).

Lee, Ha, Kim, Kim, Chang, Song, Kim: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, (2009) (PubMed).

Takahashi-Yanaga, Mori, Matsuzaki, Watanabe, Hirata, Miwa, Morimoto, Sasaguri: "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells." in: The Journal of biological chemistry, Vol. 281, Issue 50, pp. 38489-97, (2006) (PubMed).

Details zu DYRK1B

Target: DYRK1B (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1B (DYRK1B))

Andere Bezeichnung: DYRK1B

Hintergrund: DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.

Molekulargewicht: 69198

Gen-ID: 9149

NCBI Accession: NP_004705, NP_006474, NP_006475

UniProt: Q9Y463