GIPR Antikörper (N-Term)

Produktnummer ABIN391714

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GIPR in WB, IHC (p) und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für GIPR Antikörper (N-Term) (ABIN391714)

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GIPR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: RB18125

Produktdetails anti-GIPR Antikörper

Bindungsspezifität: AA 7-38, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This GIPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-38 amino acids from the N-terminal region of human GIPR.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-GIPR Antikörper (ABIN391714)

Ugleholdt, Pedersen, Bassi, Füchtbauer, Jørgensen, Kissow, Nytofte, Poulsen, Rosenkilde, Seino, Thams, Holst, Holst: "Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain." in: The Journal of biological chemistry, Vol. 286, Issue 52, pp. 44632-45, (2011) (PubMed).

Details zu GIPR

Target: GIPR (Gastric Inhibitory Polypeptide Receptor (GIPR))

Andere Bezeichnung: GIPR

Hintergrund: GIPR also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. This protein was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. The protein is involved in several other facets of the anabolic response.

Molekulargewicht: 53157

Gen-ID: 2696

NCBI Accession: NP_000155

UniProt: P48546

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling