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CD163 Antikörper (N-Term)

CD163 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB18866 unconjugated
Produktnummer ABIN391501
  • Target Alle CD163 Antikörper anzeigen
    CD163
    Bindungsspezifität
    • 16
    • 16
    • 15
    • 8
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 245-274, N-Term
    Reaktivität
    • 133
    • 50
    • 30
    • 29
    • 20
    • 5
    • 4
    • 1
    Human
    Wirt
    • 105
    • 52
    • 1
    Kaninchen
    Klonalität
    • 92
    • 65
    • 1
    Polyklonal
    Konjugat
    • 52
    • 19
    • 13
    • 8
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD163 Antikörper ist unkonjugiert
    Applikation
    • 109
    • 78
    • 51
    • 39
    • 27
    • 26
    • 25
    • 24
    • 20
    • 18
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.
    Klon
    RB18866
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CD163 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    CD163
    Andere Bezeichnung
    CD163 (CD163 Produkte)
    Synonyme
    DMBT1 antikoerper, CD163 antikoerper, CD163v2 antikoerper, CD163v3 antikoerper, M130 antikoerper, MM130 antikoerper, deleted in malignant brain tumors 1 protein-like antikoerper, CD163 molecule antikoerper, CD163 antigen antikoerper, LOC426820 antikoerper, CD163 antikoerper, Cd163 antikoerper
    Hintergrund
    CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
    Molekulargewicht
    125451
    Gen-ID
    9332
    NCBI Accession
    NP_004235, NP_981961
    UniProt
    Q86VB7
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