CD163 Antikörper (N-Term)
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- Target Alle CD163 Antikörper anzeigen
- CD163
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Bindungsspezifität
- AA 245-274, N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CD163 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Aufreinigung
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This CD163 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human CD163.
- Klon
- RB18866
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product CD163 Primärantikörper
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- Applikationshinweise
- WB: 1:1000. IHC-P: 1:10~50
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Haltbarkeit
- 6 months
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- Target
- CD163
- Andere Bezeichnung
- CD163 (CD163 Produkte)
- Synonyme
- DMBT1 antikoerper, CD163 antikoerper, CD163v2 antikoerper, CD163v3 antikoerper, M130 antikoerper, MM130 antikoerper, deleted in malignant brain tumors 1 protein-like antikoerper, CD163 molecule antikoerper, CD163 antigen antikoerper, LOC426820 antikoerper, CD163 antikoerper, Cd163 antikoerper
- Hintergrund
- CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
- Molekulargewicht
- 125451
- Gen-ID
- 9332
- NCBI Accession
- NP_004235, NP_981961
- UniProt
- Q86VB7
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