PANK2 Antikörper (AA 180-210)

Produktnummer ABIN391238

Der Kaninchen Polyklonal Anti-PANK2-Antikörper wurde für WB validiert. Er ist geeignet, PANK2 in Proben von Human zu detektieren.

Kurzübersicht für PANK2 Antikörper (AA 180-210) (ABIN391238)

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PANK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB5487

Produktdetails anti-PANK2 Antikörper

Bindungsspezifität: AA 180-210

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human PANK2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu PANK2

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Andere Bezeichnung: PANK2

Hintergrund: Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).

Molekulargewicht: 62681

Gen-ID: 80025

NCBI Accession: NP_079236, NP_705902, NP_705904

UniProt: Q9BZ23

Pathways: Ribonucleoside Biosynthetic Process