NME3 Antikörper (AA 51-81)

Produktnummer ABIN391232

Der Kaninchen Polyklonal anti-NME3 Antikörper wird verwendet zum Nachweis von NME3 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für NME3 Antikörper (AA 51-81) (ABIN391232)

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NME3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB5454

Produktdetails anti-NME3 Antikörper

Bindungsspezifität: AA 51-81

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu NME3

Target: NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3 (NME3))

Andere Bezeichnung: NME3

Hintergrund: NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34(+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

Molekulargewicht: 19015

Gen-ID: 4832

NCBI Accession: NP_002504

UniProt: Q13232

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process