LRRK2 Antikörper (AA 930-961)

Produktnummer ABIN391148

Der Kaninchen Polyklonal Anti-LRRK2-Antikörper wurde für WB und IF validiert. Er ist geeignet, LRRK2 in Proben von Human und Maus zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für LRRK2 Antikörper (AA 930-961) (ABIN391148)

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRRK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: RB07209

Produktdetails anti-LRRK2 Antikörper

Bindungsspezifität: AA 930-961

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 930-961 amino acids from human PARK8(LRRK2).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-LRRK2 Antikörper (ABIN391148)

Huang, Song, Murphy, Holton, Lashley, Revesz, Gai, Halliday: "LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions." in: Acta neuropathologica, Vol. 116, Issue 6, pp. 639-46, (2009) (PubMed).

Biskup, Moore, Rea, Lorenz-Deperieux, Coombes, Dawson, Dawson, West: "Dynamic and redundant regulation of LRRK2 and LRRK1 expression." in: BMC neuroscience, Vol. 8, pp. 102, (2008) (PubMed).

Details zu LRRK2

Target: LRRK2 (Leucine-Rich Repeat Kinase 2 (LRRK2))

Andere Bezeichnung: PARK8 (LRRK2)

Hintergrund: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.

Molekulargewicht: 286103

Gen-ID: 120892

NCBI Accession: NP_940980

UniProt: Q5S007

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development