PNCK Antikörper (C-Term)

Produktnummer ABIN391139

Der Kaninchen Polyklonal Anti-PNCK-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, PNCK in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für PNCK Antikörper (C-Term) (ABIN391139)

Target: PNCK (Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase (PNCK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PNCK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB1253-1254

Produktdetails anti-PNCK Antikörper

Bindungsspezifität: AA 314-343, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PNCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-343 amino acids from the C-terminal region of human PNCK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PNCK Antikörper (ABIN391139)

Deb, Zuo, Wang, Barndt, Cheema, Sengupta, Coticchia, Johnson: "Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex." in: American journal of physiology. Cell physiology, Vol. 300, Issue 5, pp. C1139-54, (2011) (PubMed).

Deb, Coticchia, Barndt, Zuo, Dickson, Johnson: "Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation." in: American journal of physiology. Cell physiology, Vol. 295, Issue 2, pp. C365-77, (2008) (PubMed).

Details zu PNCK

Target: PNCK (Pregnancy Up-Regulated Non-Ubiquitously Expressed CaM Kinase (PNCK))

Andere Bezeichnung: PNCK

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Molekulargewicht: 38500

Gen-ID: 139728

NCBI Accession: NP_001034671, NP_001129212

UniProt: Q6P2M8