CERK Antikörper (C-Term)

Produktnummer ABIN2841252

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CERK in WB. Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CERK Antikörper (C-Term) (ABIN2841252)

Target: CERK (Ceramide Kinase (CERK))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CERK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB5271

Produktdetails anti-CERK Antikörper

Bindungsspezifität: AA 487-516, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CERK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-516 amino acids from the C-terminal region of human CERK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CERK Antikörper (ABIN2841252)

Murakami, Ito, Hagiwara, Yoshida, Sobue, Ichihara, Takagi, Kojima, Tanaka, Tamiya-Koizumi, Kyogashima, Suzuki, Banno, Nozawa, Murate: "ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI." in: Journal of neurochemistry, Vol. 112, Issue 2, pp. 511-20, (2010) (PubMed).

Yang, Gagarin, St Laurent, Hammell, Toma, Hu, Iwasa, McCaffrey: "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 8, pp. 1213-9, (2009) (PubMed).

Hinkovska-Galcheva, Clark, VanWay, Huang, Hiraoka, Abe, Borofsky, Kunkel, Shanley, Shayman, Lanni, Petty, Boxer: "Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells." in: Journal of lipid research, Vol. 49, Issue 3, pp. 531-42, (2008) (PubMed).

Details zu CERK

Target: CERK (Ceramide Kinase (CERK))

Andere Bezeichnung: CERK

Hintergrund: Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart, brain, skeletal muscle, kidney and liver, moderate expression in peripheral blood leukocytes and thymus, and low expression in spleen, small intestine, placenta and lung.

Gen-ID: 64781

NCBI Accession: NP_073603

UniProt: Q8TCT0