MTMR4 Antikörper (C-Term)

Produktnummer ABIN390777

Produktdetails anti-MTMR4 Antikörper

Target: MTMR4 (Myotubularin Related Protein 4 (MTMR4))

Bindungsspezifität: AA 1155-1187, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTMR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MTMR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1155-1187 amino acids from the C-terminal region of human MTMR4.

Klon: RB0716

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-MTMR4 Antikörper (ABIN390777)

Yu, He, Chen, Hao, Yang, Wang, Pan, Tang: "Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 79-88, (2013) (PubMed).

Yu, Pan, Qin, Chen, Xu, Chen, Tang: "MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8454-62, (2010) (PubMed).

Plant, Correa, Goldenberg, Bain, Batt: "The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4." in: The Biochemical journal, Vol. 419, Issue 1, pp. 57-63, (2009) (PubMed).

Details zu MTMR4

Target: MTMR4 (Myotubularin Related Protein 4 (MTMR4))

Andere Bezeichnung: MTMR4 (MTMR4 Produkte)

Synonyme: zfyve11 antikoerper, fyve-dsp2 antikoerper, FYVE-DSP2 antikoerper, ZFYVE11 antikoerper, AA596759 antikoerper, ESTM44 antikoerper, mKIAA0647 antikoerper, myotubularin related protein 4 antikoerper, myotubularin related protein 4 L homeolog antikoerper, Mtmr4 antikoerper, MTMR4 antikoerper, mtmr4 antikoerper, mtmr4.L antikoerper

Hintergrund: MTMR, a member of the myotubularin family, encodes an intracellular protein of 1,195 amino acids, and shares approximately 47 % sequence identity with MTMR3, spiking to over 70 % identity in the catalytic domain and the double zinc finger (FYVE) motif. PCR analysis detects expression of MTMR4 in all human tissues examined except lung, small intestine, stomach, salivary gland, adrenal gland, and uterus. Subcellular localization of MTMR4 in transfected HeLa cells showed a perinuclear distribution, similar to that seen with MTMR3. MTMR4 dephosphorylates para-nitrophenylphosphate and phosphatidylinositol 3-phosphate.

Molekulargewicht: 133353

Gen-ID: 9110

NCBI Accession: NP_004678

UniProt: Q9NYA4

Pathways: Inositol Metabolic Process