Sclerostin Antikörper (N-Term)

Produktnummer ABIN390193

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Sclerostin in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für Sclerostin Antikörper (N-Term) (ABIN390193)

Target: Sclerostin (SOST)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sclerostin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB12388

Produktdetails anti-Sclerostin Antikörper

Bindungsspezifität: AA 12-42, N-Term

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the N-terminal region of human SOST.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:2000. WB: 1:1000. WB: 1:2000. IHC-P-Leica: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-Sclerostin Antikörper (ABIN390193)

Zarei, Hulley, Sabokbar, Javaid: "Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips." in: Calcified tissue international, Vol. 100, Issue 6, pp. 609-618, (2018) (PubMed).

Lin, Lin, Chang, Wang, Lai: "Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation." in: Bioelectromagnetics, Vol. 36, Issue 7, pp. 494-505, (2015) (PubMed).

Details zu Sclerostin

Target: Sclerostin (SOST)

Andere Bezeichnung: SOST

Hintergrund: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Molekulargewicht: 24031

Gen-ID: 50964

NCBI Accession: NP_079513

UniProt: Q9BQB4