SIRT6 Antikörper (C-Term)

Produktnummer ABIN390181

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIRT6 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für SIRT6 Antikörper (C-Term) (ABIN390181)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2109

Produktdetails anti-SIRT6 Antikörper

Bindungsspezifität: AA 290-319, C-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SIRT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-319 amino acids from the C-terminal region of human SIRT6.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:500. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-SIRT6 Antikörper (ABIN390181)

Li, Shi, Yang, Yan, Zhang, Yang, He, Li, Yi, Sun, Liang, Cheng, Shi, Shang, Yu: "SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability." in: Nature communications, Vol. 7, pp. 12235, (2018) (PubMed).

Wang, Zhang, Liang, Zhang, Xu, Zhang, Fuji, Mu, Li, Jiang, Ju, Wang: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." in: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).

Wu, Liu, Fu, Liu, Zhou: "Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients." in: Annals of clinical and laboratory science, Vol. 44, Issue 4, pp. 410-8, (2014) (PubMed).

Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." in: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

Details zu SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Andere Bezeichnung: SIRT6

Hintergrund: SIRT6 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Molekulargewicht: 39119

Gen-ID: 51548

NCBI Accession: NP_001180214, NP_057623

UniProt: Q8N6T7