SIRT3 Antikörper (C-Term)

Produktnummer ABIN390178

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SIRT3 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus und wurde in 11+ Publikationen erwähnt.

Kurzübersicht für SIRT3 Antikörper (C-Term) (ABIN390178)

Target: SIRT3 (Sirtuin 3 (SIRT3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB01967

Produktdetails anti-SIRT3 Antikörper

Bindungsspezifität: AA 250-279, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SIRT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the C-terminal region of human SIRT3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-SIRT3 Antikörper (ABIN390178)

Schwab, Sison, Meade, Broniowska, Corbett, Ebert: "Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons." in: Stem cell reports, Vol. 9, Issue 6, pp. 1839-1852, (2018) (PubMed).

Takumida, Takumida, Katagiri, Anniko: "Localization of sirtuins (SIRT1-7) in the aged mouse inner ear." in: Acta oto-laryngologica, pp. 1-12, (2015) (PubMed).

He, Hu, Shi, Weidert, Lu, Xu, Huang, Kelley, Xie: "Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3." in: Molecular and cellular biology, Vol. 33, Issue 10, pp. 2047-55, (2013) (PubMed).

Kamarajan, Alhazzazi, Danciu, Dsilva, Verdin, Kapila: "Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis." in: Cancer, Vol. 118, Issue 23, pp. 5800-10, (2012) (PubMed).

Parker, Vazquez-Manrique, Tourette, Farina, Offner, Mukhopadhyay, Orfila, Darbois, Menet, Tissenbaum, Neri: "Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 36, pp. 12630-40, (2012) (PubMed).

Caton, Holness, Bishop-Bailey, Sugden: "PPAR?-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status." in: The Biochemical journal, Vol. 437, Issue 3, pp. 521-30, (2011) (PubMed).

Xiong, Salazar, Patrushev, Alexander: "FoxO1 mediates an autofeedback loop regulating SIRT1 expression." in: The Journal of biological chemistry, Vol. 286, Issue 7, pp. 5289-99, (2011) (PubMed).

Alhazzazi, Kamarajan, Joo, Huang, Verdin, DSilva, Kapila: "Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer." in: Cancer, Vol. 117, Issue 8, pp. 1670-8, (2011) (PubMed).

Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: "Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 3133-44, (2010) (PubMed).

Sundaresan, Gupta, Kim, Rajamohan, Isbatan, Gupta: "Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice." in: The Journal of clinical investigation, Vol. 119, Issue 9, pp. 2758-71, (2009) (PubMed).

Sundaresan, Samant, Pillai, Rajamohan, Gupta: "SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70." in: Molecular and cellular biology, Vol. 28, Issue 20, pp. 6384-401, (2008) (PubMed).

Details zu SIRT3

Target: SIRT3 (Sirtuin 3 (SIRT3))

Andere Bezeichnung: SIRT3

Hintergrund: SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The SIRT3 is included in class I of the sirtuin family.

Molekulargewicht: 43573

Gen-ID: 23410

NCBI Accession: NP_001017524, NP_036371

UniProt: Q9NTG7