IMMT Antikörper (AA 438-467)

Produktnummer ABIN389477

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-IMMT Antikörper wird verwendet zum Nachweis von IMMT in Proben von Human. Er wurde validiert für WB, FACS und IHC (p).

Kurzübersicht für IMMT Antikörper (AA 438-467) (ABIN389477)

Target: IMMT (Inner Membrane Protein, Mitochondrial (IMMT))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IMMT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB20815

Produktdetails anti-IMMT Antikörper

Bindungsspezifität: AA 438-467

Homologie: M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This IMMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-467 amino acids from the Central region of human IMMT.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-IMMT Antikörper (ABIN389477)

Steffen, Vashisht, Wan, Jen, Claypool, Wohlschlegel, Koehler: "Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria." in: Molecular biology of the cell, Vol. 28, Issue 5, pp. 600-612, (2017) (PubMed).

Details zu IMMT

Target: IMMT (Inner Membrane Protein, Mitochondrial (IMMT))

Andere Bezeichnung: IMMT

Hintergrund: Mitochondria are the center of cellular energy production and essential metabolic reactions. As double membrane-bound organelles, mitochondria from different species, tissues, and metabolic states are highly polymorphic in nature, yet exhibit common structural features. The ultrastructural variations in mitochondrial architecture occur mainly due to the differences in the amount and shape of cristae. Abundant cristae are found in mitochondria from tissues where energy demand is high. Analysis of the human heart mitochondrial proteome shows that mitofilin is one of the most abundant mitochondrial proteins. It appears to play an important role in the maintenance of cristae morphology.

Molekulargewicht: 83678

Gen-ID: 10989

NCBI Accession: NP_001093639, NP_001093640, NP_006830

UniProt: Q16891